The internal mechanism and knife holder rest on a heavy and rigid base to render a shake proof operation. The latest designed protective cover is hinged to the base and swings back so that the interior parts will be completely exposed for cleaning, lubrication and setting etc. the feed mechanism is dependent on the vertical movement of the object block. With every complete revolution of the counter balanced drive wheel the feed pawl engages precisely on to the gear which moves towards and advances the object holder thought a cone, inclined plane mechanism in such a precise increment that tissues can be sectioned even in one-micron thickness. When the limit of the feed is reached at the end, a safety device automatically disengages the feed mechanism to prevent jamming and damage to the feed screws. The feed indicator is located in the front and feed setting is controlled by a knurled knob at the back of the microtome, to adjust section thickness from 1-50 microns in steps of one micron each. The sturdy knife holder is addition to knife elevating and leveling provides lateral movements for complete use of knife edge.